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Multicellular aligned bands disrupt global collective cell behavior

https://doi.org/10.1016/j.actbio.2022.10.041

Jebeli, Mahvash; Lopez, Samantha K.; Goldblatt, Zachary E.; McCollum, Dannel; Mana-Capelli, Sebastian; Wen, Qi; Billiar, Kristen (June 2023, Acta Biomaterialia)

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Heterogeneity Profoundly Alters Emergent Stress Fields in Constrained Multicellular Systems

https://doi.org/10.1016/j.bpj.2019.11.018

Goldblatt, Zachary E.; Ashouri Choshali, Habibeh; Cirka, Heather A.; Liang, Vivian; Wen, Qi; McCollum, Dannel; Rahbar, Nima; Billiar, Kristen L. (January 2020, Biophysical Journal)

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Introduction of Heterogeneous Cell Properties for Modeling Emergent Stress Fields in Multicellular Systems

Goldblatt, Zachary E; Cirka, Heather A; Ashouri Choshali, Habibeh; Rahbar, Nima; McCollum, Dannel; Billiar, Kristen L (June 2019, Summer Biomechanics, Biotransport, and Bioengineering Meeting)

We present the first experimental evidence that supports that low stresses are experienced by central cells and is driving the biological response of aggregates. Our model improves upon previous models, however, it can still become more robust. We plan to obtain higher resolution biophysical data with validation to further alter cell contractility distributions and iterate our model’s parameters. It is necessary to incorporate heterogeneous mechanical properties to accurately estimate the distribution of the emergent stress fields in our aggregates.
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